As with all catheterization procedures, care should be. Cathflo activase contains no antibacterial preservatives and should be reconstituted immediately before use. Activase side effects, uses, dosage, overdose, pregnancy. Questions about pd vote up 0 vote down resolved public gail g, nurse from georgia asked is there a protocol in the use of activase for pd cath. There are two activase dose regimens accelerated and 3hour for use in the management. It can be used as a thrombolytic agent to hydrolyse fibrin and fibrinogen. Activase therapy for acute ischemic stroke management. Patients can be booked into the renal day care ward on ext.
Before using dosing system the steris acusinq chemical dosing system figure 1 is a dispensing system used to transfer precise amounts of presoak chemicals into a prewash sink. Activase belongs to a group of drugs called thrombolytics. Cathflo activase alteplase for injection is a sterile, white to pale yellow, lyophilized powder for intracatheter instillation for restoration of function to central venous access devices following reconstitution with sterile water for injection, usp. Cathflo dosing and administration card for adult patients. Activase alteplase is indicated for the treatment of acute ischemic stroke ais. Introduction to pharmacokinetics and pharmacodynamics. It is a sterile, purified glycoprotein of 527 amino acids. Activase is a prescription medication used to break up or dissolve blood clots. Assess for menses in women, recent surgery or trauma, bleeding disorders, or history of.
Any local ems system changes to this document must follow the nc oems. This information will be given to you, along with exact instructions and a dosing sheet. Fatal cases of hemorrhage associated with traumatic intubation in patients administered activase have been reported. Obtain complete health history, including allergies, drug history, and possible drug interactions. The recommended treatment dose is 100 mg administered by intravenous iv infusion over 2 hours. Initiate treatment as soon as possible but within 3 hours after symptom onset. Exclude intracranial hemorrhage as the primary cause of stroke signs and symptoms prior to initiation of treatment see contraindications 4. Exclude intracranial hemorrhage as the primary cause of stroke signs and symptoms prior to initiation of treatment. The infusion should begin immediately following the bolus. During and following activase administration for the treatment of acute ischemic stroke, frequently monitor and control blood pressure. Your childs doctor will determine the appropriate dose by taking into account your childs weight, height, age, and other factors. Extravasation of activase infusion can cause ecchymosis or inflammation. Acute ischemic stroke intravenous thrombolysis chart.
Nonfibrinbound tpa does not extensively activate plasminogen. Webmd provides common contraindications for cathflo activase intracatheter. Reperfusion therapy for acute myocardial infarction jason s. Patients receiving alteplase assessment prior to administration. Activase alteplase is indicated for the treatment of acute ischemic stroke. Find out what health conditions may be a health risk when taken with cathflo activase intracatheter. Our practice is to reconstitute 8 mgs of activase in 10 ccs of saline. Alteplase tpa treatment for peritonitis and peritoneal catheter malfunction, alteplase tpa is a fibrinolytic agent. Highlights of prescribing information acute ischemic. Pdr drug summaries are concise pointofcare prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice pdr s drug summaries are available free of charge and serve as a great resource for us based mds, dos, nps and pas in patient practice. Using cathflo activase in patients with infected catheters may release a localized infection into the systemic circulation. Fbn 2459 and the north carolina nurses association. Activase can cause significant, sometimes fatal internal or external bleeding. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient.
Optimising the combination dosing strategy of abemaciclib and vemurafenib in brafmutated melanoma xenograft tumours article pdf available in british journal of cancer 1146. Avoid intramuscular injections and trauma to the patient. Institute parenteral anticoagulation near the end of or immediately following the activase infusion when the partial thromboplastin time or thrombin time returns to twice normal or less. Activase is for intravenous iv administration only. If extravasation occurs, terminate the infusion at that iv site and apply local therapy. Administer activase as soon as possible but within 3 hours after onset of symptoms. These conditions are more commonly known as heart attack and stroke, respectively. Cathflo 2 mg is the standard of care for treatment of thrombotically occluded catheters. This chemical dosing system uses an electronically controlled peristaltic pump to.
A patient that keeps staph epi peritonitis after treatment with antibiotics 1 answer vote up 0 vote down public asktheexpertteam. Aggrastat is a reversible antagonist of fibrinogen binding to the gp iibiiia receptor, the major platelet surface receptor involved in platelet aggregation. Perform venipunctures carefully and only as required. Dailymed cathflo activase alteplase injection, powder. A healthcare provider will give you this injection. Activase definition of activase by medical dictionary. These dissolve blood clots quickly to help restart blood flow to the heart and helps prevent damage to the heart muscle. Clinical applicants specialist bracco diagnostics inc. Consent to administer alteplase tpa i understand that.
Using sterile technique, remove the mini cap or other catheter cap, attach the syringe and gently inject the whole 10ccs. Consent to administer alteplase tpa physician name. Indications activase alteplase is indicated for the treatment of acute ischemic stroke. As the public becomes more informed about the signs and symptoms of stroke, people are. When administered intravenously, aggrastat inhibits ex vivo platelet aggregation in a dose and concentrationdependent manner. Guidelines for use of tpa activase treatment in acute ischemic stroke physician to check appropriate boxes treatment of acute ischemic stroke with tpa activase must be initiated within 3 hours of stroke symptom onset. Alteplase injection activase is a tissue plasminogen activator produced by recombinant dna technology.
Reconstitution, dosing, and administration narrator reads the following script while pharmacist demonstrates the steps for reconstituting intravenous rtpa. Cathflo activase alteplase 2 cathflo activase 3 alteplase 4 powder for reconstitution for use in central venous access 5 devices 6 description 7 cathflo activase alteplase is a tissue plasminogen activator tpa 8 produced by recombinant dna technology. Thrombolytic pregnancy risk category c action converts plasminogen to plasmin, which in turn breaks down fibrin and fibrinogen, thereby dissolving thrombus availability injection. Teiken, md, surgical and combined intensive care units gary e. Cathflo activase should be used with caution in the presence of known or suspected infection in the catheter. Evaluating patient eligibility, dosing and administration, activase post.
The seattle ii a prospective, singearm, multicenter trial of ekosonicr endovascular system and activase for treatment of acute pulmonary embolism study, 48 was a single arm multicenter trial of uacdt that demonstrated improved right ventricular hemodynamic indices in patients undergoing uacdt for both massive and submassive pe. If you continue browsing the site, you agree to the use of cookies on this website. Some of the dosage forms listed on this page may not apply to the brand name activase in summary. Alteplase tpa lyses fibrin clots within the catheter lumen which may.
Patients receiving alteplase potential nursing diagnoses. Have second practitioner independently check original order, dose calculations, and infusion pump settings. Activase alteplase dose, indications, adverse effects. Inclusion criteria all yes boxes must be checked before thrombolytics are given yes no. Cathflo activase alteplase powder for reconstitution for. Follow these guidelines for the dosing and administration of activase 6. There are two activase dose regimens accelerated and 3hour for use in. Alteplase is indicated for use in the management of acute myocardial infarction, ischemic stroke, and for the management of acute massive pulmonary embolism pe in adults. Activity and dosage of alteplase dilution for clearing occlusions of venousaccess devices. What is the procedure for activase dwell in a pd catheter.
Introduction in this video, we will demonstrate how to reconstitute, dose, and administer alteplase, or. Alteplase twice on two separate occassions within a two week period. Contraindications for cathflo activase intracatheter. Do not confuse the abbreviation tpa for alteplase activase with the abbreviations tnk tpa for tenecteplase tnkase and rpa for reteplase retevase. It is synthesized using the complementary dna cdna for natural human tissue. Tnkase tenecteplase is a tissue plasminogen activator tpa produced by. Fibrinolytic agents alteplase recombinant tissuetype plasminogen activator, tpa naturally occurring enzyme serine protease in contrast to streptokinase, it is fibrinspecific fibrinbound tpa has increased affinity for plasminogen and enhances its activation. A version of this article originally appeared on the emergency medicine pharmd blog. Go, md, facc interventional cardiology and peripheral vascular intervention altru health system.
This document contains side effect information about alteplase. Pdf effects of alteplase in the treatment of acute ischemic stroke. Patients with acute ischemic stroke who underwent alteplaseinduced. Thus, only the recommended dose of alteplase was used for. The recommended total dose should not exceed 50 mg and is. Is there a protocol in the use of activase for pd cath. Ismp s list of confused drug names contains lookalike and soundalike lasa name pairs, of medications that have been published in the ismp medication safety alert.
Monitoring patients in the first 24 hours activase. Activase is used to break up a fibrin clot in the pd catheter. Guidelines on the administration of actilyse beaumont hospital. Actilyse uk, activase, activase rtpa ca, cathflo activase pharmacologic class. Cathflo activase genentech, drug reference encyclopedia. Reperfusion therapy for acute myocardial infarction.
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